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Issue 6, 2015
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Degradable polyphosphoester-based silver-loaded nanoparticles as therapeutics for bacterial lung infections

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Abstract

In this study, a new type of degradable polyphosphoester-based polymeric nanoparticle, capable of carrying silver cations via interactions with alkyne groups, has been developed as a potentially effective and safe treatment for lung infections. It was found that up to 15% (w/w) silver loading into the nanoparticles could be achieved, consuming most of the pendant alkyne groups along the backbone, as revealed by Raman spectroscopy. The well-defined Ag-loaded nanoparticles released silver in a controlled and sustained manner over 5 days, and displayed enhanced in vitro antibacterial activities against cystic fibrosis-associated pathogens and decreased cytotoxicity to human bronchial epithelial cells, in comparison to silver acetate.

Graphical abstract: Degradable polyphosphoester-based silver-loaded nanoparticles as therapeutics for bacterial lung infections

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Supplementary files

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Submitted
01 Dec 2014
Accepted
29 Dec 2014
First published
09 Jan 2015

Nanoscale, 2015,7, 2265-2270
Article type
Communication
Author version available

Degradable polyphosphoester-based silver-loaded nanoparticles as therapeutics for bacterial lung infections

F. Zhang, J. A. Smolen, S. Zhang, R. Li, P. N. Shah, S. Cho, H. Wang, J. E. Raymond, C. L. Cannon and K. L. Wooley, Nanoscale, 2015, 7, 2265
DOI: 10.1039/C4NR07103D

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