Manipulating directional cell motility using intracellular superparamagnetic nanoparticles

Michael Bradshaw; Tristan D. Clemons; Diwei Ho; Lucía Gutiérrez; Francisco J. Lázaro; Michael J. House; Timothy G. St. Pierre; Mark W. Fear; Fiona M. Wood; K. Swaminathan Iyer

doi:10.1039/C4NR06594H

Manipulating directional cell motility using intracellular superparamagnetic nanoparticles†

Michael Bradshaw,^ab Tristan D. Clemons,^ab Diwei Ho,^a Lucía Gutiérrez,^cd Francisco J. Lázaro,^e Michael J. House,^c Timothy G. St. Pierre,^c Mark W. Fear,^bf Fiona M. Wood^bfg and K. Swaminathan Iyer*^a

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* Corresponding authors

^a School of Chemistry and Biochemistry, M313, The University of Western Australia, 35 Stirling Highway, Crawley, WA, Australia
E-mail: swaminatha.iyer@uwa.edu.au

^b Fiona Wood Foundation, Burn Injury Research Unit, M509, The University of Western Australia, 35 Stirling Highway, Crawley, WA, Australia

^c Biomagnetics Research Group, School of Physics, M013, The University of Western Australia, 35 Stirling Highway, Crawley, WA, Australia

^d Department of Biomaterials and Bioinspired Materials, Instituto de Ciencia de Materiales de Madrid (ICMM)/CSIC, 28049 Madrid, Spain

^e Departamento de Ciencia y Tecnología de Materiales y Fluidos, Universidad de Zaragoza, Zaragoza, Spain

^f Burn Injury research Unit, School of Surgery, The University of Western Australia, 35 Stirling Highway, Crawley, WA, Australia

^g Burns Service of Western Australia, Department of Health, Perth CBD, WA, Australia

Abstract

This study investigated the ability for magnetic nanoparticles to influence cellular migration in the presence of an external magnetic field. We found that the direction of migrating keratinocytes can be controlled and the migration speed of fibroblasts can be increased with the internalisation of these nanoparticles in the presence of a magnetic field. The possibility of shepherding cells towards a region of interest through the use of internalized nanoparticles is an attractive prospect for cell tracking, cell therapies, and tissue engineering applications.

Nanoscale

Manipulating directional cell motility using intracellular superparamagnetic nanoparticles†

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