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Issue 5, 2015
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The marine actinomycete genus Salinispora: a model organism for secondary metabolite discovery

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Abstract

Covering: 2001 to 2014

This review covers the initial discovery of the marine actinomycete genus Salinispora through its development as a model for natural product research. A focus is placed on the novel chemical structures reported with reference to their biological activities and the synthetic and biosynthetic studies they have inspired. The time line of discoveries progresses from more traditional bioassay-guided approaches through the application of genome mining and genetic engineering techniques that target the products of specific biosynthetic gene clusters. This overview exemplifies the extraordinary biosynthetic diversity that can emanate from a narrowly defined genus and supports future efforts to explore marine taxa in the search for novel natural products.

Graphical abstract: The marine actinomycete genus Salinispora: a model organism for secondary metabolite discovery

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Article information


Submitted
30 Dec 2014
First published
02 Mar 2015

Nat. Prod. Rep., 2015,32, 738-751
Article type
Review Article

The marine actinomycete genus Salinispora: a model organism for secondary metabolite discovery

P. R. Jensen, B. S. Moore and W. Fenical, Nat. Prod. Rep., 2015, 32, 738
DOI: 10.1039/C4NP00167B

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