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Issue 4, 2015
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Ester coupling reactions – an enduring challenge in the chemical synthesis of bioactive natural products

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Abstract

Covering: up to 2014

In this review we investigate the use of complex ester fragment couplings within natural product total synthesis campaigns. We first outline the different biosynthetic and chemical strategies for performing complex ester couplings and on this mechanistic background we then present and discuss a collection of successful examples from the literature.

Graphical abstract: Ester coupling reactions – an enduring challenge in the chemical synthesis of bioactive natural products

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Article information


Submitted
12 Aug 2014
First published
09 Jan 2015

Nat. Prod. Rep., 2015,32, 605-632
Article type
Review Article
Author version available

Ester coupling reactions – an enduring challenge in the chemical synthesis of bioactive natural products

M. Tsakos, E. S. Schaffert, L. L. Clement, N. L. Villadsen and T. B. Poulsen, Nat. Prod. Rep., 2015, 32, 605
DOI: 10.1039/C4NP00106K

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