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Issue 11, 2015
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Energy efficient, facile and cost effective methodology for formation of an inclusion complex of resveratrol with hp-β-CD

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Abstract

A distinctive, effortless, proficient and innovative process for preparation of an inclusion complex (IC) of resveratrol (Res) with hp-β-CD was developed. The methodology overcame the hindrance of low solubility of Res which is a potential anticancer agent and makes its use more practical. The strategy involved the utilization of a microwave meant for conventional use and the process of sonication in the laboratory. It considerably saved time and labour besides cutting down on energy consumption. The prepared inclusion complexes were characterised by FTIR, UV-visible absorption spectroscopy, NMR, TGA, DSC, XRD and CHNS analysis. Phase solubility studies along with Gaussian studies proved the formation of a 1 : 1 complex whose physical nature and stability were studied using XRD and UV-visible absorption spectroscopy, respectively. This effortless and economical process could pave the way for the formation of inclusion complexes of other nutraceuticals and pharmaceuticals.

Graphical abstract: Energy efficient, facile and cost effective methodology for formation of an inclusion complex of resveratrol with hp-β-CD

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Article information


Submitted
14 Apr 2015
Accepted
31 Aug 2015
First published
02 Sep 2015

New J. Chem., 2015,39, 8855-8865
Article type
Paper
Author version available

Energy efficient, facile and cost effective methodology for formation of an inclusion complex of resveratrol with hp-β-CD

K. Kaur, S. Uppal, R. Kaur, J. Agarwal and S. K. Mehta, New J. Chem., 2015, 39, 8855
DOI: 10.1039/C5NJ00924C

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