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Issue 11, 2015
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Energy efficient, facile and cost effective methodology for formation of an inclusion complex of resveratrol with hp-β-CD

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Abstract

A distinctive, effortless, proficient and innovative process for preparation of an inclusion complex (IC) of resveratrol (Res) with hp-β-CD was developed. The methodology overcame the hindrance of low solubility of Res which is a potential anticancer agent and makes its use more practical. The strategy involved the utilization of a microwave meant for conventional use and the process of sonication in the laboratory. It considerably saved time and labour besides cutting down on energy consumption. The prepared inclusion complexes were characterised by FTIR, UV-visible absorption spectroscopy, NMR, TGA, DSC, XRD and CHNS analysis. Phase solubility studies along with Gaussian studies proved the formation of a 1 : 1 complex whose physical nature and stability were studied using XRD and UV-visible absorption spectroscopy, respectively. This effortless and economical process could pave the way for the formation of inclusion complexes of other nutraceuticals and pharmaceuticals.

Graphical abstract: Energy efficient, facile and cost effective methodology for formation of an inclusion complex of resveratrol with hp-β-CD

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Publication details

The article was received on 14 Apr 2015, accepted on 31 Aug 2015 and first published on 02 Sep 2015


Article type: Paper
DOI: 10.1039/C5NJ00924C
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New J. Chem., 2015,39, 8855-8865

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    Energy efficient, facile and cost effective methodology for formation of an inclusion complex of resveratrol with hp-β-CD

    K. Kaur, S. Uppal, R. Kaur, J. Agarwal and S. K. Mehta, New J. Chem., 2015, 39, 8855
    DOI: 10.1039/C5NJ00924C

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