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Issue 6, 2015
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Design and synthesis of sugar-triazole based uracil appended sugar-imine derivatives – an application in DNA binding studies

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Abstract

Several sugar-triazole derivatives were synthesized and characterized by spectroscopic techniques. The interaction of the sugar-triazoles with CT-DNA was explored, which revealed that all the compounds could interact with CT-DNA through groove binding, which was further supported by a docking analysis.

Graphical abstract: Design and synthesis of sugar-triazole based uracil appended sugar-imine derivatives – an application in DNA binding studies

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Article information


Submitted
03 Dec 2014
Accepted
30 Mar 2015
First published
30 Mar 2015

New J. Chem., 2015,39, 4575-4582
Article type
Paper
Author version available

Design and synthesis of sugar-triazole based uracil appended sugar-imine derivatives – an application in DNA binding studies

A. Hemamalini, E. R. Azhagiya Singam, S. K. Mudedla, V. Subramanian and T. Mohan Das, New J. Chem., 2015, 39, 4575
DOI: 10.1039/C4NJ02221A

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