cis-2-Aminocyclohex-4-enecarboxylic acid as a new building block of helical foldamers

Abstract

cis-2-Aminocyclohex-4-enecarboxylic acid (cis-ACHE) is a conformationally constrained β-amino acid. We showed that the conformational preference of a cis-ACHE residue is similar to that of cis-2-aminocyclohexanecarboxylic acid. α/β-Peptides that consist of the alternation of (1S,2R)-cis-ACHE and L-alanine adopted 11/9-helical conformations in solution and in the crystal state.