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Issue 1, 2015
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DNA-interacting and biological properties of copper(II) complexes from amidino-O-methylurea

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Abstract

The interaction of two copper(II) complexes, namely [Cu(L1)Cl2]2 (1) and [Cu(L2)Cl2]2 (2), where L1 = 1-amidino-O-methylurea and L2 = N-(benzyl)-amidino-O-methylurea, with DNA has been thoroughly investigated using different characterization techniques, including electronic absorption spectroscopy, viscosity measurements, fluorescence spectroscopy, circular dichroism spectroscopy, thermal denaturation, stoichiometric determination, gel electrophoresis and atomic-force microscopy. The coordination compounds exhibit DNA binding potential by non-intercalation and DNA-cleaving ability through the oxidative pathway. Indeed, both complexes display antibacterial properties (against three bacteria involved in human-food poisoning, i.e. Salmonella, E. coli and Campylobacter). Furthermore, their cytotoxicity has been tested against three cancer cell lines, which are the small cell lung carcinoma (NCI-H187), the oral cavity carcinoma (KB) and the breast adenocarcinoma (MCF-7) and it was revealed that they are more cytotoxic than cisplatin against the NCI-H187 cancer cell line.

Graphical abstract: DNA-interacting and biological properties of copper(ii) complexes from amidino-O-methylurea

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Publication details

The article was received on 14 Aug 2014, accepted on 04 Nov 2014 and first published on 14 Nov 2014


Article type: Paper
DOI: 10.1039/C4NJ01377H
Citation: New J. Chem., 2015,39, 664-675
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    DNA-interacting and biological properties of copper(II) complexes from amidino-O-methylurea

    A. Meenongwa, R. F. Brissos, C. Soikum, P. Chaveerach, P. Gamez, Y. Trongpanich and U. Chaveerach, New J. Chem., 2015, 39, 664
    DOI: 10.1039/C4NJ01377H

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