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Issue 8, 2015
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Protective activity of carnosine and anserine against zinc-induced neurotoxicity: a possible treatment for vascular dementia

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Abstract

Carnosine (β-alanyl-L-histidine) is a small dipeptide with numerous beneficial effects, including the maintenance of the acid–base balance, antioxidant properties, chelating agent, anti-crosslinking, and anti-glycation activities. High levels of carnosine and its analogue anserine (1-methyl carnosine) are found in skeletal muscle and the brain. Zinc (Zn)-induced neurotoxicity plays a crucial role in the pathogenesis of vascular dementia (VD), and carnosine inhibits Zn-induced neuronal death. Here, the protective activity of carnosine against Zn-induced neurotoxicity and its molecular mechanisms such as cellular Zn influx and Zn-induced gene expression were investigated using immortalised hypothalamic neurons (GT1-7 cells). Carnosine and anserine protected against Zn-induced neurotoxicity not by preventing increases in intracellular Zn2+ but by participating in the regulation of the endoplasmic reticulum (ER) stress pathway and the activity-regulated cytoskeletal protein (Arc). Accordingly, carnosine and anserine protected against neurotoxicity induced by ER-stress inducers thapsigargin and tunicamycin. Hence, carnosine and anserine are expected to have future therapeutic potential for VD and other neurodegenerative diseases.

Graphical abstract: Protective activity of carnosine and anserine against zinc-induced neurotoxicity: a possible treatment for vascular dementia

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Publication details

The article was received on 17 Feb 2015, accepted on 24 Mar 2015 and first published on 24 Mar 2015


Article type: Paper
DOI: 10.1039/C5MT00049A
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Citation: Metallomics, 2015,7, 1233-1239

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    Protective activity of carnosine and anserine against zinc-induced neurotoxicity: a possible treatment for vascular dementia

    D. Mizuno, K. Konoha-Mizuno, M. Mori, Y. Sadakane, H. Koyama, S. Ohkawara and M. Kawahara, Metallomics, 2015, 7, 1233
    DOI: 10.1039/C5MT00049A

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