Jump to main content
Jump to site search
PLANNED MAINTENANCE Close the message box

Scheduled maintenance work on Wednesday 27th March 2019 from 11:00 AM to 1:00 PM (GMT).

During this time our website performance may be temporarily affected. We apologise for any inconvenience this might cause and thank you for your patience.


Issue 3, 2015
Previous Article Next Article

The English (H6R) familial Alzheimer's disease mutation facilitates zinc-induced dimerization of the amyloid-β metal-binding domain

Author affiliations

Abstract

Interaction of Zn2+ with the metal-binding domain of the English (H6R) amyloid-β mutant results in the formation of peptide dimers. The mutation causes the exclusion of His6 from the zinc chelation pattern observed in the intact domain and triggers the assembly of the dimers via zinc ions coordinated by 11EVHH14 fragments.

Graphical abstract: The English (H6R) familial Alzheimer's disease mutation facilitates zinc-induced dimerization of the amyloid-β metal-binding domain

Back to tab navigation

Supplementary files

Publication details

The article was received on 01 Oct 2014, accepted on 13 Feb 2015 and first published on 13 Feb 2015


Article type: Communication
DOI: 10.1039/C4MT00259H
Author version
available:
Download author version (PDF)
Citation: Metallomics, 2015,7, 422-425

  •   Request permissions

    The English (H6R) familial Alzheimer's disease mutation facilitates zinc-induced dimerization of the amyloid-β metal-binding domain

    S. A. Kozin, A. A. Kulikova, A. N. Istrate, P. O. Tsvetkov, S. S. Zhokhov, Y. V. Mezentsev, O. I. Kechko, A. S. Ivanov, V. I. Polshakov and A. A. Makarov, Metallomics, 2015, 7, 422
    DOI: 10.1039/C4MT00259H

Search articles by author

Spotlight

Advertisements