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Issue 7, 2015
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Enhanced in vitro and in vivo uptake of a hydrophobic model drug coumarin-6 in the presence of cucurbit[7]uril

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Abstract

This report describes, for the first time, cucurbit[7]uril-assisted quantitative in vitro and in vivo uptake of a hydrophobic model drug, coumarin-6, by both an epithelial cell model and a zebrafish model. The transcellular delivery pathway study suggested multiple mechanisms involved, including macropinocytosis, clathrin and lipid raft-mediated endocytosis/exocytosis.

Graphical abstract: Enhanced in vitro and in vivo uptake of a hydrophobic model drug coumarin-6 in the presence of cucurbit[7]uril

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Publication details

The article was received on 30 Apr 2015, accepted on 12 Jun 2015 and first published on 12 Jun 2015


Article type: Concise Article
DOI: 10.1039/C5MD00189G
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Citation: Med. Chem. Commun., 2015,6, 1370-1374
  • Open access: Creative Commons BY-NC license
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    Enhanced in vitro and in vivo uptake of a hydrophobic model drug coumarin-6 in the presence of cucurbit[7]uril

    X. Miao, Y. Li, I. Wyman, S. M. Y. Lee, D. H. Macartney, Y. Zheng and R. Wang, Med. Chem. Commun., 2015, 6, 1370
    DOI: 10.1039/C5MD00189G

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