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Issue 7, 2015
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Medicinal organometallic chemistry – an emerging strategy for the treatment of neglected tropical diseases

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Abstract

Organometallic moieties make excellent candidates for lead structures in drug design, due to their bioactivity, redox chemistry and structural diversity. Despite this, only a limited number of organometallic compounds have been recruited in combatting neglected tropical diseases, 17 of which are officially recognised by the World Health Organisation. New pharmaceuticals are needed to overcome the prominent side effects of existing treatments for these diseases, as well as to avoid emerging resistance genes in the causative parasites. This review focuses on the use of organometallic drug compounds in treating African sleeping sickness (Human African trypanosomiasis), Chagas disease (American trypanosomiasis), leishmaniasis, schistosomiasis and echinococcosis. Studies from the past 5–10 years have generated promising lead compounds, most arising from the modification of an existing drug and all demonstrating the advantageous properties unique to organometallic chemistry. Most of the compounds introduced here remain in the lead identification stage and require further in vivo and physiochemical studies.

Graphical abstract: Medicinal organometallic chemistry – an emerging strategy for the treatment of neglected tropical diseases

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Publication details

The article was received on 23 Apr 2015, accepted on 25 May 2015 and first published on 26 May 2015


Article type: Review Article
DOI: 10.1039/C5MD00174A
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Citation: Med. Chem. Commun., 2015,6, 1230-1243

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    Medicinal organometallic chemistry – an emerging strategy for the treatment of neglected tropical diseases

    R. W. Brown and C. J. T. Hyland, Med. Chem. Commun., 2015, 6, 1230
    DOI: 10.1039/C5MD00174A

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