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Issue 1, 2015
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Naphthoquinone-based chalcone hybrids and derivatives: synthesis and potent activity against cancer cell lines

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Abstract

Novel naphthoquinone-based chalcones were prepared from the reaction between 3-bromo-nor-β-lapachone and amino-chalcones. Lapachone derivatives are also described here. All the substances were evaluated against cancer and normal cell lines and several compounds demonstrated potent antitumor activity.

Graphical abstract: Naphthoquinone-based chalcone hybrids and derivatives: synthesis and potent activity against cancer cell lines

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Supplementary files

Article information


Submitted
28 Aug 2014
Accepted
19 Sep 2014
First published
24 Sep 2014

Med. Chem. Commun., 2015,6, 120-130
Article type
Concise Article

Naphthoquinone-based chalcone hybrids and derivatives: synthesis and potent activity against cancer cell lines

G. A. M. Jardim, T. T. Guimarães, M. D. C. F. R. Pinto, B. C. Cavalcanti, K. M. de Farias, C. Pessoa, C. C. Gatto, D. K. Nair, I. N. N. Namboothiri and E. N. da Silva Júnior, Med. Chem. Commun., 2015, 6, 120
DOI: 10.1039/C4MD00371C

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