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Issue 1, 2015
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Naphthoquinone-based chalcone hybrids and derivatives: synthesis and potent activity against cancer cell lines

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Abstract

Novel naphthoquinone-based chalcones were prepared from the reaction between 3-bromo-nor-β-lapachone and amino-chalcones. Lapachone derivatives are also described here. All the substances were evaluated against cancer and normal cell lines and several compounds demonstrated potent antitumor activity.

Graphical abstract: Naphthoquinone-based chalcone hybrids and derivatives: synthesis and potent activity against cancer cell lines

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Publication details

The article was received on 28 Aug 2014, accepted on 19 Sep 2014 and first published on 24 Sep 2014


Article type: Concise Article
DOI: 10.1039/C4MD00371C
Citation: Med. Chem. Commun., 2015,6, 120-130

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    Naphthoquinone-based chalcone hybrids and derivatives: synthesis and potent activity against cancer cell lines

    G. A. M. Jardim, T. T. Guimarães, M. D. C. F. R. Pinto, B. C. Cavalcanti, K. M. de Farias, C. Pessoa, C. C. Gatto, D. K. Nair, I. N. N. Namboothiri and E. N. da Silva Júnior, Med. Chem. Commun., 2015, 6, 120
    DOI: 10.1039/C4MD00371C

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