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Issue 7, 2015
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The PI3K/AKT/mTOR interactive pathway

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Abstract

The phosphatidylinositol 3-kinase (PI3K)/AKT/mammalian target of the rapamycin (mTOR) signalling pathway is hyperactivated or altered in many cancer types and regulates a broad range of cellular processes including survival, proliferation, growth, metabolism, angiogenesis and metastasis. The PI3K/AKT/mTOR pathway is regulated by a wide-range of upstream signalling proteins and it regulates many downstream effectors by collaborating with various compensatory signalling pathways, primarily with RAF/MEK/ERK pathway. Limited clinical success of the available targeted therapeutic agents and challenges mediated by tumour heterogeneity across different cancer types emphasize the importance of alterations in the PI3K/AKT/mTOR pathway in the design of effective personalized treatment strategies. Here we report a comprehensive PI3K/AKT/mTOR network that represents the intricate crosstalk between compensatory pathways, which can be utilized to study the AKT signalling mechanism in detail and improve the personalized combinatorial therapeutic strategies.

Graphical abstract: The PI3K/AKT/mTOR interactive pathway

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Supplementary files

Article information


Submitted
03 Feb 2015
Accepted
17 Apr 2015
First published
20 Apr 2015

Mol. BioSyst., 2015,11, 1946-1954
Article type
Paper
Author version available

The PI3K/AKT/mTOR interactive pathway

T. Ersahin, N. Tuncbag and R. Cetin-Atalay, Mol. BioSyst., 2015, 11, 1946
DOI: 10.1039/C5MB00101C

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