Jump to main content
Jump to site search

Issue 8, 2015
Previous Article Next Article

Magnetophoresis ‘meets’ viscoelasticity: deterministic separation of magnetic particles in a modular microfluidic device

Author affiliations

Abstract

The deflection of magnetic beads in a microfluidic channel through magnetophoresis can be improved if the particles are somehow focused along the same streamline in the device. We design and fabricate a microfluidic device made of two modules, each one performing a unit operation. A suspension of magnetic beads in a viscoelastic medium is fed to the first module, which is a straight rectangular-shaped channel. Here, the magnetic particles are focused by exploiting fluid viscoelasticity. Such a channel is one inlet of the second module, which is a H-shaped channel, where a buffer stream is injected in the second inlet. A permanent magnet is used to displace the magnetic beads from the original to the buffer stream. Experiments with a Newtonian suspending fluid, where no focusing occurs, are carried out for comparison. When viscoelastic focusing and magnetophoresis are combined, magnetic particles can be deterministically separated from the original streamflow to the buffer, thus leading to a high deflection efficiency (up to ~96%) in a wide range of flow rates. The effect of the focusing length on the deflection of particles is also investigated. Finally, the proposed modular device is tested to separate magnetic and non-magnetic beads.

Graphical abstract: Magnetophoresis ‘meets’ viscoelasticity: deterministic separation of magnetic particles in a modular microfluidic device

Back to tab navigation

Publication details

The article was received on 28 Jan 2015, accepted on 20 Feb 2015 and first published on 20 Feb 2015


Article type: Paper
DOI: 10.1039/C5LC00106D
Lab Chip, 2015,15, 1912-1922

  •   Request permissions

    Magnetophoresis ‘meets’ viscoelasticity: deterministic separation of magnetic particles in a modular microfluidic device

    F. Del Giudice, H. Madadi, M. M. Villone, G. D'Avino, A. M. Cusano, R. Vecchione, M. Ventre, P. L. Maffettone and P. A. Netti, Lab Chip, 2015, 15, 1912
    DOI: 10.1039/C5LC00106D

Search articles by author

Spotlight

Advertisements