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Issue 1, 2015
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Cancer stem cells: small subpopulation or evolving fraction?

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Central to the debate about cancer stem cells in solid tumors is the proportion of cells that can initiate, propagate, and re-initiate tumors. An initially assumed minor subpopulation is confronted with recent data suggesting as many as 30% of primary tumor cells have stem cell characteristics. This review discusses quantitative modeling studies that augment our understanding of stem and non-stem cancer cell interactions during tumor progression and the resulting fraction of cancer stem cells. A discussion of how these findings can be carefully evaluated in novel, integrated interdisciplinary studies is offered.

Graphical abstract: Cancer stem cells: small subpopulation or evolving fraction?

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Publication details

The article was received on 07 Aug 2014, accepted on 24 Oct 2014 and first published on 24 Oct 2014

Article type: Critical Review
DOI: 10.1039/C4IB00191E
Integr. Biol., 2015,7, 14-23
  • Open access: Creative Commons BY license

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