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Issue 5, 2015
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Direct amidation of carboxylic acids with amines under microwave irradiation using silica gel as a solid support

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Abstract

A highly improved and green methodology for the direct amidation of carboxylic acids with amines using silica gel as a solid support and catalyst is described. The scope of this method is exemplified by the use of several aliphatic, aromatic, unsaturated and fatty acids. The reaction is also applied to different primary and secondary amines. Typically, the amines should be aliphatic, but aromatic amines can be used as well, though with lower yields. Several experiments to illustrate the selectivity of this methodology were also carried out with several more functionalized acids and amines. This approach is a substantial improvement over other previously described methods in amide synthesis.

Graphical abstract: Direct amidation of carboxylic acids with amines under microwave irradiation using silica gel as a solid support

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Supplementary files

Article information


Submitted
28 Jan 2015
Accepted
05 Apr 2015
First published
07 Apr 2015

Green Chem., 2015,17, 3157-3163
Article type
Paper
Author version available

Direct amidation of carboxylic acids with amines under microwave irradiation using silica gel as a solid support

A. Ojeda-Porras, A. Hernández-Santana and D. Gamba-Sánchez, Green Chem., 2015, 17, 3157
DOI: 10.1039/C5GC00189G

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