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Issue 3, 2015
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On water: catalyst-free chemoselective synthesis of highly functionalized tetrahydroquinazolines from 2-aminophenylacrylate

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Abstract

A green and catalyst-free atom-ecomonic straightforward tandem approach for the synthesis of highly functionalized tetrahydroquinazolines by the reaction of 2-aminophenylacrylates with isothiocyanates using water as an environmentally friendly solvent via amidation and concomitant chemoselective Michael-addition is described.

Graphical abstract: On water: catalyst-free chemoselective synthesis of highly functionalized tetrahydroquinazolines from 2-aminophenylacrylate

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Article information


Submitted
05 Nov 2014
Accepted
11 Jan 2015
First published
13 Jan 2015

Green Chem., 2015,17, 1434-1441
Article type
Communication
Author version available

On water: catalyst-free chemoselective synthesis of highly functionalized tetrahydroquinazolines from 2-aminophenylacrylate

R. K. Saunthwal, M. Patel, R. K. Tiwari, K. Parang and A. K. Verma, Green Chem., 2015, 17, 1434
DOI: 10.1039/C4GC02154A

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