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Issue 1, 2015
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A novel D-glucosamine-derived pyridyl-triazole@palladium catalyst for solvent-free Mizoroki–Heck reactions and its application in the synthesis of Axitinib

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Abstract

A green method for the synthesis of a D-glucosamine-derived triazole@palladium catalyst is described. The synthesized catalyst containing a 2-pyridyl-1,2,3-triazole ligand was prepared via a click route in high yields and was explored in Heck cross-coupling reactions between different aryl halides and olefins under solvent-free conditions. The catalyst can be separated from the reaction mixture and reused at least six times with superior activity. In addition, using this protocol, the marketed drug Axitinib (antitumor) could be synthesized easily.

Graphical abstract: A novel d-glucosamine-derived pyridyl-triazole@palladium catalyst for solvent-free Mizoroki–Heck reactions and its application in the synthesis of Axitinib

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Publication details

The article was received on 18 Aug 2014, accepted on 09 Oct 2014 and first published on 13 Oct 2014


Article type: Communication
DOI: 10.1039/C4GC01606H
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Green Chem., 2015,17, 225-230

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    A novel D-glucosamine-derived pyridyl-triazole@palladium catalyst for solvent-free Mizoroki–Heck reactions and its application in the synthesis of Axitinib

    C. Shen, H. Shen, M. Yang, C. Xia and P. Zhang, Green Chem., 2015, 17, 225
    DOI: 10.1039/C4GC01606H

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