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Issue 12, 2015
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Anti-inflammatory activity of horseradish (Armoracia rusticana) root extracts in LPS-stimulated macrophages

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Abstract

Horseradish (Armoracia rusticana) is a perennial crop belonging to the Brassicaceae family. Horseradish root is used as a condiment due to its extremely pungent flavour, deriving from the high content of glucosinolates and their breakdown products such as isothiocyanates and other sulfur compounds. Horseradish also has a long history in ethnomedicine. In this study the anti-inflammatory potential of three accessions of Armoracia rusticana on lipopolysaccharide from E. coli treated J774A.1 murine macrophages was evaluated. Our results demonstrate that Armoracia rusticana reduced nitric oxide, tumor necrosis factor-α and interleukin-6 release and nitric oxide synthase and cyclooxygenase-2 expression in macrophages, acting on nuclear transcription factor NF-κB p65 activation. Moreover Armoracia rusticana reduced reactive oxygen species release and increased heme-oxygenase-1 expression, thus contributing to the cytoprotective cellular effect during inflammation.

Graphical abstract: Anti-inflammatory activity of horseradish (Armoracia rusticana) root extracts in LPS-stimulated macrophages

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Publication details

The article was received on 30 Apr 2015, accepted on 08 Sep 2015 and first published on 15 Sep 2015


Article type: Paper
DOI: 10.1039/C5FO00475F
Food Funct., 2015,6, 3778-3788

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    Anti-inflammatory activity of horseradish (Armoracia rusticana) root extracts in LPS-stimulated macrophages

    S. Marzocco, L. Calabrone, S. Adesso, M. Larocca, S. Franceschelli, G. Autore, G. Martelli and R. Rossano, Food Funct., 2015, 6, 3778
    DOI: 10.1039/C5FO00475F

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