Jump to main content
Jump to site search

Issue 1, 2015
Previous Article Next Article

Interactions of flavan-3-ols and procyanidins with membranes: mechanisms and the physiological relevance

Author affiliations

Abstract

Flavonoids are a type of phenolic compound widely present in edible plants. A great number of health benefits have been ascribed to flavonoid consumption in the human population. However, the molecular mechanisms involved in such effects remain to be identified. The flavan-3-ols (−)-epicatechin and (+)-catechin, and their related oligomers (procyanidins) have been thoroughly studied because of their capacity to interact with cell membranes. Starting with these interactions, procyanidins could modulate multiple biochemical processes, such as enzyme activities, receptor-ligand binding, membrane-initiated cell signaling, and molecule transport across membranes. This review focuses on molecular aspects of procyanidin interactions with membrane lipid components, and the resulting protection of the membranes against mechanical and/or oxidative damage, resulting in the maintenance of cell functions.

Graphical abstract: Interactions of flavan-3-ols and procyanidins with membranes: mechanisms and the physiological relevance

Back to tab navigation

Publication details

The article was received on 21 Jul 2014, accepted on 22 Oct 2014 and first published on 23 Oct 2014


Article type: Review Article
DOI: 10.1039/C4FO00647J
Author version
available:
Download author version (PDF)
Food Funct., 2015,6, 32-40

  •   Request permissions

    Interactions of flavan-3-ols and procyanidins with membranes: mechanisms and the physiological relevance

    S. V. Verstraeten, C. G. Fraga and P. I. Oteiza, Food Funct., 2015, 6, 32
    DOI: 10.1039/C4FO00647J

Search articles by author

Spotlight

Advertisements