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Issue 46, 2015
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Ultra-small mesoporous silica nanoparticles as efficient carriers for pH responsive releases of anti-cancer drugs

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Abstract

Mesoporous silica has emerged as one of the most promising carriers for drug delivery systems. However, the synthesis of ultra-small mesoporous silica nanoparticles (UMSNs) and their application in drug delivery remains a significant challenge. Here, spherical UMSNs (∼25 nm) have been synthesized and tested as drug carriers. Anti-cancer drugs mitoxantrone (MX), doxorubicin (DOX) and methotrexate (MTX) have been utilized as model drugs. The pH-responsive drug delivery system can be constructed based on electrostatic interactions between carriers and drug molecules. The UMSNs could store drugs under physiological conditions and release them under acidic conditions. Different pH-responsive release profiles were obtained in phosphate buffer solutions (PBSs) at the designed pH values (from 4.0 to 7.4). MX and DOX can be used in the pH-responsive delivery system, while MTX cannot be used. Furthermore, we found that the physiological stabilities of these drug molecules in UMSNs are in a decreasing order MX > DOX > MTX, which follows the order of their isoelectric point (pI) values.

Graphical abstract: Ultra-small mesoporous silica nanoparticles as efficient carriers for pH responsive releases of anti-cancer drugs

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Publication details

The article was received on 22 Sep 2015, accepted on 22 Oct 2015 and first published on 22 Oct 2015


Article type: Paper
DOI: 10.1039/C5DT03700J
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Dalton Trans., 2015,44, 20186-20192

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    Ultra-small mesoporous silica nanoparticles as efficient carriers for pH responsive releases of anti-cancer drugs

    H. Zheng, C. Tai, J. Su, X. Zou and F. Gao, Dalton Trans., 2015, 44, 20186
    DOI: 10.1039/C5DT03700J

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