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Issue 36, 2015
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The effect of potential supramolecular-bond promoters on the DNA-interacting abilities of copper–terpyridine compounds

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Abstract

Three copper(II) coordination compounds have been prepared from three different 2,2′:6′,2′′-terpyridine-based ligands, which have been selected to investigate the potential role of supramolecular interactions on the DNA-interacting and cytotoxicity properties of the corresponding metal complexes. Hence, the ligands 4′-((naphthalen-2-yl)methoxy)-2,2′:6′,2′′-terpyridine (Naphtpy) and 4′-((1H-benzo[d]imidazol-2-yl)methoxy)-2,2′:6′,2′′-terpyridine (Bimztpy) have been synthesized from commercially-available 4′-chloro-2,2′:6′,2′′-terpyridine (Cltpy), and their copper(II) complexes have been obtained by reaction with copper(II) nitrate. The DNA-interacting abilities of the corresponding compounds [Cu(Cltpy)(H2O)(NO3)2] (1), [Cu(naphtpy)(NO3)(H2O)](NO3)(MeOH) (2) and [Cu(bimztpy)(NO3)(H2O)](NO3) (3) have been investigated using different techniques, and cytotoxicity assays with several cancer cell lines have revealed interesting features, viz. the more efficient complex is 2, which although it does not act as a DNA cleaver, displays the most effective DNA-interacting and cytotoxic properties, compared to 1 and 3.

Graphical abstract: The effect of potential supramolecular-bond promoters on the DNA-interacting abilities of copper–terpyridine compounds

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Publication details

The article was received on 10 Jun 2015, accepted on 31 Jul 2015 and first published on 03 Aug 2015


Article type: Paper
DOI: 10.1039/C5DT02211H
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Citation: Dalton Trans., 2015,44, 16061-16072
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    The effect of potential supramolecular-bond promoters on the DNA-interacting abilities of copper–terpyridine compounds

    J. Grau, R. F. Brissos, J. Salinas-Uber, A. B. Caballero, A. Caubet, O. Roubeau, L. Korrodi-Gregório, R. Pérez-Tomás and P. Gamez, Dalton Trans., 2015, 44, 16061
    DOI: 10.1039/C5DT02211H

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