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Issue 41, 2015
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The cytotoxicity of gold nanoparticles is dispersity-dependent

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Abstract

Nanoparticles are generally dispersed in electrolyte solutions for cell research. They may be aggregated and thus strongly influence the subsequent bio-effects. However, this has been often neglected in nanotoxicity research. In this paper, we selected gold nanoparticles as an example and investigated the role of dispersity in cytotoxicity. Our data indicated that the cytotoxicity of aggregated gold nanoparticles is significantly higher than well-dispersed ones. The dispersity-dependent cytotoxicity may be related to the increase of cellular endocytosis and reactive oxygen species. These results highlighted the importance of the dispersity of nanoparticles in nanotoxicity and nanobiotechnology fields.

Graphical abstract: The cytotoxicity of gold nanoparticles is dispersity-dependent

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Article information


Submitted
04 Jun 2015
Accepted
10 Aug 2015
First published
10 Aug 2015

Dalton Trans., 2015,44, 17911-17915
Article type
Communication

The cytotoxicity of gold nanoparticles is dispersity-dependent

D. Huang, H. Zhou, H. Liu and J. Gao, Dalton Trans., 2015, 44, 17911
DOI: 10.1039/C5DT02118A

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