Brønsted acid-catalyzed 1,2-fluorine migration with fluoroepoxides
A catalytic 1,2-fluorine migration reaction with simple fluoroepoxides at room temperature is reported. Under Brønsted acid catalysis, α-fluorinated ketones are efficiently constructed in the absence of an external fluorine source through a 1,2-fluorine migration reaction. The experimental results indicate that the present 1,2-fluorine migration reaction proceeds via a carbocation intermediate.
- This article is part of the themed collection: Fluorine