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Issue 34, 2015
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Light-induced nitric oxide release from physiologically stable porous coordination polymers

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Abstract

The development of nitric oxide (NO) releasing materials has been of significant importance due to their application in cell biology and biomedicine. Besides the macromolecular scaffold dangling NO releasing moiety, porous materials have been used to host such NO releasing molecules. Here we synthesized a series of porous coordination polymers (PCPs), in which N-nitrosamine functional groups as photoactive NO donors were introduced into the framework scaffolds by post-synthetic nitrosation of amine functionalized analogous PCPs. We further demonstrated a controlled release of NO from the PCPs by light irradiation. Though isoreticular frameworks based on octanuclear clusters of titanium or aluminium ions were chosen due to their water-stability, the frameworks showed difference in stability in cell culture media; while aluminium frameworks were less stable in water and physiological media, the titanium analogue was highly stable even under physiological conditions.

Graphical abstract: Light-induced nitric oxide release from physiologically stable porous coordination polymers

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Supplementary files

Article information


Submitted
14 Apr 2015
Accepted
21 Jul 2015
First published
21 Jul 2015

Dalton Trans., 2015,44, 15324-15333
Article type
Paper

Light-induced nitric oxide release from physiologically stable porous coordination polymers

C. Kim, S. Diring, S. Furukawa and S. Kitagawa, Dalton Trans., 2015, 44, 15324
DOI: 10.1039/C5DT01418B

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