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Issue 15, 2015
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Tetranuclear ruthenium(ii) complexes with oligo-oxyethylene linkers as one- and two-photon luminescent tracking non-viral gene vectors

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Abstract

To prolong the observation time, increase the penetration depth and decrease self-absorption and phototoxicity, two-photon luminescent vectors have emerged as promising tools for tracking gene delivery in living cells. Herein, we report four new tetranuclear Ru(II) complexes based on oligo-oxyethylene and polybenzimidazole as one- and two- photon luminescent tracking non-viral gene vectors. In such a molecular design, the oligo-oxyethylene, polybenzimidazole and Ru(II) polypyridyl complexes were expected to render the vectors with increased cell permeability, biocompatibility, proton buffering capacity and one- and two-photon luminescence. Corresponding DNA interaction studies showed that the ability of the complexes to condense DNA decreased with increasing oligo-oxyethylene lengths. Additionally, all complexes protected DNA. The complexes were investigated as one- and two-photon tracking non-viral gene vectors in living cells and showed proper cellular uptake, good luciferase expression and low cytotoxicity.

Graphical abstract: Tetranuclear ruthenium(ii) complexes with oligo-oxyethylene linkers as one- and two-photon luminescent tracking non-viral gene vectors

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Supplementary files

Article information


Submitted
11 Jan 2015
Accepted
07 Mar 2015
First published
09 Mar 2015

Dalton Trans., 2015,44, 7058-7065
Article type
Paper

Tetranuclear ruthenium(II) complexes with oligo-oxyethylene linkers as one- and two-photon luminescent tracking non-viral gene vectors

K. Qiu, B. Yu, H. Huang, P. Zhang, L. Ji and H. Chao, Dalton Trans., 2015, 44, 7058
DOI: 10.1039/C5DT00117J

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