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Issue 27, 2015
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Selective hydration of nitriles to amides catalysed by PCP pincer supported nickel(ii) complexes

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Abstract

The (PCP)Ni–OH complexes 2R (R = iPr, tBu, Cy) are effective catalyst precursors for the selective hydration of nitriles to the corresponding amides under relatively mild conditions (80 °C) and low catalyst loadings (0.05–0.5%). Substrate scope includes aliphatic, vinylic and aromatic nitriles, but substrates with protic groups poison the catalyst abruptly. The catalysts are effective because the electron rich nature of the PCP ligands and their steric bulk renders the hydroxo group labile.

Graphical abstract: Selective hydration of nitriles to amides catalysed by PCP pincer supported nickel(ii) complexes

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Supplementary files

Article information


Submitted
17 Dec 2014
Accepted
06 Jan 2015
First published
07 Jan 2015

Dalton Trans., 2015,44, 12082-12085
Article type
Communication
Author version available

Selective hydration of nitriles to amides catalysed by PCP pincer supported nickel(II) complexes

J. Borau-Garcia, D. V. Gutsulyak, R. J. Burford and W. E. Piers, Dalton Trans., 2015, 44, 12082
DOI: 10.1039/C4DT03902E

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