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Issue 27, 2015
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Selective hydration of nitriles to amides catalysed by PCP pincer supported nickel(II) complexes

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Abstract

The (PCP)Ni–OH complexes 2R (R = iPr, tBu, Cy) are effective catalyst precursors for the selective hydration of nitriles to the corresponding amides under relatively mild conditions (80 °C) and low catalyst loadings (0.05–0.5%). Substrate scope includes aliphatic, vinylic and aromatic nitriles, but substrates with protic groups poison the catalyst abruptly. The catalysts are effective because the electron rich nature of the PCP ligands and their steric bulk renders the hydroxo group labile.

Graphical abstract: Selective hydration of nitriles to amides catalysed by PCP pincer supported nickel(ii) complexes

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Publication details

The article was received on 17 Dec 2014, accepted on 06 Jan 2015 and first published on 07 Jan 2015


Article type: Communication
DOI: 10.1039/C4DT03902E
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Dalton Trans., 2015,44, 12082-12085

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    Selective hydration of nitriles to amides catalysed by PCP pincer supported nickel(II) complexes

    J. Borau-Garcia, D. V. Gutsulyak, R. J. Burford and W. E. Piers, Dalton Trans., 2015, 44, 12082
    DOI: 10.1039/C4DT03902E

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