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Issue 4, 2015
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One-pot synthesis of an indole-substituted 7,8-dicarba-nido-dodecahydroundecaborate(−1)

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Abstract

Carbaboranes are increasingly used as pharmacophores to replace phenyl substituents in established drug molecules. In contrast to traditional organic chemistry, elaborate procedures to introduce functionality frequently fail in the case of carbaboranes and their chemistry is often hampered by degradation of the cluster. Herein, the development of a one-pot synthesis of a water-soluble N-nido-dicarbaborato indole is presented, including a proposed mechanism for the reaction sequence. These studies provide useful synthetic tools for the conjugation of two important pharmacophores, indoles and carbaboranes.

Graphical abstract: One-pot synthesis of an indole-substituted 7,8-dicarba-nido-dodecahydroundecaborate(−1)

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Supplementary files

Article information


Submitted
18 Oct 2014
Accepted
18 Nov 2014
First published
19 Nov 2014

This article is Open Access

Dalton Trans., 2015,44, 1748-1753
Article type
Paper
Author version available

One-pot synthesis of an indole-substituted 7,8-dicarba-nido-dodecahydroundecaborate(−1)

W. Neumann, R. Frank and E. Hey-Hawkins, Dalton Trans., 2015, 44, 1748
DOI: 10.1039/C4DT03218G

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