Issue 1, 2015
From the journal:

Dalton Transactions

Platinum(ii) clovers targeting G-quadruplexes and their anticancer activities†

Xiao-Hui Zheng,‡a   Qian Cao,‡a   Yi-Liang Ding,a   Yi-Fang Zhong,a   Ge Mu,a   Peter Z. Qin,b   Liang-Nian Jia  and  Zong-Wan Mao*a  

* Corresponding authors

a MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, China
E-mail: cesmzw@mail.sysu.edu.cn
Fax: (+86)2084112245

b Department of Chemistry, University of Southern California, Los Angeles, California 90089, USA

Abstract

Two porphyrin-bridged tetranuclear platinum(II) complexes are found to effectively stabilize various kinds of G-quadruplexes. Their clover-like shape endows them with the capability of targeting G-quadruplexes rather than the double-stranded structure. Their excellent anticancer activity is the result of a dual effect, inhibition of the telomerase activity and repression of oncogene expression.

Graphical abstract: Platinum(ii) clovers targeting G-quadruplexes and their anticancer activities

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Article information

DOI
https://doi.org/10.1039/C4DT02760D
Article type
Communication
Submitted
10 Sep 2014
Accepted
22 Oct 2014
First published
22 Oct 2014

Dalton Trans., 2015,44, 50-53

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Platinum(II) clovers targeting G-quadruplexes and their anticancer activities

X. Zheng, Q. Cao, Y. Ding, Y. Zhong, G. Mu, P. Z. Qin, L. Ji and Z. Mao, Dalton Trans., 2015, 44, 50 DOI: 10.1039/C4DT02760D

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