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Issue 2, 2015
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Tuning the coordination properties of phenothiazine by regioselective introduction of diphenylphosphanyl groups

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Abstract

The palladium and platinum complexes of the newly synthesized 1-(diphenylphosphino)-10-methyl-10H-phenothiazine (1) and the previously reported 3-(diphenylphosphino)-10-alkyl-10H-phenothiazine [alkyl = Me (2), Et (3)] and 4-(diphenylphosphino)-10-ethyl-10H-phenothiazine (4) were prepared. Density functional calculations were carried out to explain the electronic properties of compounds 1, 3 and 4. Compounds 1, 3 and 4 can interact with DNA, as was observed in agarose gel electrophoresis experiments. In addition, the cytotoxicity of the platinum complexes of ligands 2 and 4 towards breast, colorectal and hepatocarcinoma cell lines was studied.

Graphical abstract: Tuning the coordination properties of phenothiazine by regioselective introduction of diphenylphosphanyl groups

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Supplementary files

Article information


Submitted
01 Sep 2014
Accepted
27 Oct 2014
First published
27 Oct 2014

Dalton Trans., 2015,44, 615-629
Article type
Paper
Author version available

Tuning the coordination properties of phenothiazine by regioselective introduction of diphenylphosphanyl groups

I. H. Filip, E. Gál, I. Lupan, M. Perde-Schrepler, P. Lönnecke, M. Surducan, L. I. Găină, E. Hey-Hawkins and L. Silaghi-Dumitrescu, Dalton Trans., 2015, 44, 615
DOI: 10.1039/C4DT02665A

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