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Issue 5, 2015
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Selective NaOH-catalysed hydration of aromatic nitriles to amides

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Abstract

The selective synthesis of aromatic and heteroaromatic amides through base-catalysed hydration of nitriles was achieved using inexpensive and commercially available NaOH as the only catalyst. A wide range of nitriles was selectively converted to their corresponding amides. Kinetic studies show that the double hydration of nitriles towards undesirable carboxylic acids is negligible under our reaction conditions.

Graphical abstract: Selective NaOH-catalysed hydration of aromatic nitriles to amides

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Article information


Submitted
03 Mar 2015
Accepted
18 Mar 2015
First published
24 Mar 2015

Catal. Sci. Technol., 2015,5, 2865-2868
Article type
Paper

Selective NaOH-catalysed hydration of aromatic nitriles to amides

T. E. Schmid, A. Gómez-Herrera, O. Songis, D. Sneddon, A. Révolte, F. Nahra and C. S. J. Cazin, Catal. Sci. Technol., 2015, 5, 2865
DOI: 10.1039/C5CY00313J

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