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Issue 23, 2015
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Biomolecular engineering of virus-like particles aided by computational chemistry methods

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Abstract

Virus-like particles (VLPs) are repetitive organizations of viral proteins assembled in an appropriate physicochemical environment. VLPs can stimulate both innate and adaptive immune responses, due to their particulate structure enabling uptake by antigen presenting cells. These characteristics have led to successful development of VLP-vaccine products, and will ensure their vast potential in years to come. Future success of VLP therapeutic products will be determined by advances in their bioengineering, and also by the development of tools to design for their stability, function and application. This review focuses on approaches for VLP assembly in controlled chemical environments in vivo and in vitro, and the application of computational tools for improved chemical sequence design, and fundamental understanding of assembly.

Graphical abstract: Biomolecular engineering of virus-like particles aided by computational chemistry methods

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Publication details

The article was received on 03 Jul 2015 and first published on 18 Sep 2015


Article type: Review Article
DOI: 10.1039/C5CS00526D
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Chem. Soc. Rev., 2015,44, 8608-8618

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    Biomolecular engineering of virus-like particles aided by computational chemistry methods

    L. Zhang, L. H. L. Lua, A. P. J. Middelberg, Y. Sun and N. K. Connors, Chem. Soc. Rev., 2015, 44, 8608
    DOI: 10.1039/C5CS00526D

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