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Issue 22, 2015
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Carbohydrate nanocarriers in biomedical applications: functionalization and construction

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Abstract

The specific targeting of either tumor cells or immune cells in vivo by carefully designed and appropriately surface-functionalized nanocarriers may become an effective therapeutic treatment for a variety of diseases. Carbohydrates, which are prominent biomolecules, have shown their outstanding ability in balancing the biocompatibility, stability, biodegradability, and functionality of nanocarriers. The recent applications of sugar (mono/oligosaccharides and/or polysaccharides) for the development of nanomedicines are summarized in this review, including the application of carbohydrates for the surface-functionalization of various nanocarriers and for the construction of the nanocarrier itself. Current problems and challenges are also addressed.

Graphical abstract: Carbohydrate nanocarriers in biomedical applications: functionalization and construction

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Article information


Submitted
31 Jan 2015
First published
17 Aug 2015

This article is Open Access

Chem. Soc. Rev., 2015,44, 8301-8325
Article type
Review Article
Author version available

Carbohydrate nanocarriers in biomedical applications: functionalization and construction

B. Kang, T. Opatz, K. Landfester and F. R. Wurm, Chem. Soc. Rev., 2015, 44, 8301
DOI: 10.1039/C5CS00092K

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