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Issue 39, 2015
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Structural self-organization of C60 and cisplatin in physiological solution

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Abstract

The specific features of structural self-organization of C60 fullerene and antitumor drug cisplatin (Cis) in physiological solution (0.9% NaCl) have been investigated by means of small-angle neutron scattering, scanning electron and atomic force microscopies, as well as isothermal titration calorimetry, dynamic light scattering and UV-Vis spectroscopy. The formation of C60 + Cis complexes, has been reported, unveiling the mechanism of medico-biological synergy observed during administration of the mixture of these drugs.

Graphical abstract: Structural self-organization of C60 and cisplatin in physiological solution

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Publication details

The article was received on 09 May 2015, accepted on 17 Aug 2015 and first published on 17 Sep 2015


Article type: Paper
DOI: 10.1039/C5CP02688A
Phys. Chem. Chem. Phys., 2015,17, 26084-26092

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    Structural self-organization of C60 and cisplatin in physiological solution

    Yu. I. Prylutskyy, V. V. Cherepanov, M. P. Evstigneev, O. A. Kyzyma, V. I. Petrenko, V. I. Styopkin, L. A. Bulavin, N. A. Davidenko, D. Wyrzykowski, A. Woziwodzka, J. Piosik, R. Kaźmierkiewicz and U. Ritter, Phys. Chem. Chem. Phys., 2015, 17, 26084
    DOI: 10.1039/C5CP02688A

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