Jump to main content
Jump to site search

Issue 27, 2015
Previous Article Next Article

Chiral discrimination by a cellulose polymer: differential crystallization inhibition of enantiomers in amorphous dispersions

Author affiliations

Abstract

With the goal of better understanding how polymers inhibit crystallization in amorphous solid dispersions, crystal growth rates of the R and S enantiomers of a model chiral compound in the presence of chiral and achiral polymers were evaluated. The crystal growth rates of enantiomers in undercooled melts were inhibited to different extents by the same mass fraction of a chiral polymer, hydroxypropylmethyl cellulose acetate succinate. This is most likely due to differences in the ability of each enantiomer to form hydrogen bonding interactions with the polymer, which in turn impacts the crystallization behavior of the low molecular weight organic compound. In contrast, the achiral polymer polyvinylpyrrolidone, and the chiral polymer, hydroxypropylmethylcellulose phthalate showed the same inhibitory impact on each enantiomer.

Graphical abstract: Chiral discrimination by a cellulose polymer: differential crystallization inhibition of enantiomers in amorphous dispersions

Back to tab navigation

Supplementary files

Article information


Submitted
25 Apr 2015
Accepted
09 Jun 2015
First published
10 Jun 2015

CrystEngComm, 2015,17, 5046-5053
Article type
Paper

Chiral discrimination by a cellulose polymer: differential crystallization inhibition of enantiomers in amorphous dispersions

T. Sato and L. S. Taylor, CrystEngComm, 2015, 17, 5046
DOI: 10.1039/C5CE00810G

Social activity

Search articles by author

Spotlight

Advertisements