Issue 93, 2015
From the journal:

Chemical Communications

Combinatorial therapy for triple negative breast cancer using hyperstar polymer-based nanoparticles†

S. K. Misra,a   X. Wang,b   I. Srivastava,a   M. K. Imgruet,a   R. W. Graff,b   A. Ohoka,a   T. L. Kampert,a   H. Gao*b  and  D. Pan*a  

* Corresponding authors

a Department of Bioengineering, Beckman Institute for Advanced Science and Technology, Materials Science and Engineering, Carle Foundation Hospital, University of Illinois at Urbana-Champaign, and Carle Foundation Hospital, 502 N. Busey, Urbana, USA
E-mail: dipanjan@illinois.edu

b Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46556, USA
E-mail: hgao@nd.edu

Abstract

We report the ability of a novel combinatorial therapy obtained from nanoparticles of hyperstar polymers encompassing drugs to selectively target triple negative breast cancer (TNBC) cell proliferation through STAT3 and topoisomerase-II pathways. This nano-cocktail was at least two to four fold better than the individual drugs and 6–20 times more selective than the parent drugs.

Graphical abstract: Combinatorial therapy for triple negative breast cancer using hyperstar polymer-based nanoparticles

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Article information

DOI
https://doi.org/10.1039/C5CC07709E
Article type
Communication
Submitted
15 Sep 2015
Accepted
21 Sep 2015
First published
22 Sep 2015

Chem. Commun., 2015,51, 16710-16713

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Combinatorial therapy for triple negative breast cancer using hyperstar polymer-based nanoparticles

S. K. Misra, X. Wang, I. Srivastava, M. K. Imgruet, R. W. Graff, A. Ohoka, T. L. Kampert, H. Gao and D. Pan, Chem. Commun., 2015, 51, 16710 DOI: 10.1039/C5CC07709E

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