Issue 95, 2015
From the journal:

Chemical Communications

A fluorescent probe for specific detection of cysteine in the lipid dense region of cells†

Firoj Ali,a   Anila H. A.,a   Nandaraj Taye,b   Rajesh G. Gonnade,c   Samit Chattopadhyay*b  and  Amitava Das*a  

* Corresponding authors

a Organic Chemistry Division, CSIR-National Chemical Laboratory, Pune-411008, India
E-mail: a.das@ncl.res.in
Tel: +91 2025902385

b Chromatin and Disease Biology Lab, National Centre for Cell Science, Pune 411007, India
E-mail: samit@nccs.res.in

c Center for Materials Characterization, CSIR-National Chemical Laboratory, Pune-411008, India

Abstract

A new cysteine (Cys) specific chemodosimetric reagent (ER-F) is used in imaging of endogenous Cys localized in the lipid dense region of the live Hct116 cells and the release of Cys within HepG2 cells from a drug following a biochemical transformation. A silica surface, modified with ER-F, could be used for quantitative estimation of Cys present in aqueous solution (pH 7.2) and in a human blood plasma (HBP).

Graphical abstract: A fluorescent probe for specific detection of cysteine in the lipid dense region of cells

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Article information

DOI
https://doi.org/10.1039/C5CC07450A
Article type
Communication
Submitted
04 Sep 2015
Accepted
24 Sep 2015
First published
24 Sep 2015

Chem. Commun., 2015,51, 16932-16935

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A fluorescent probe for specific detection of cysteine in the lipid dense region of cells

F. Ali, A. H. A., N. Taye, R. G. Gonnade, S. Chattopadhyay and A. Das, Chem. Commun., 2015, 51, 16932 DOI: 10.1039/C5CC07450A

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