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Issue 1, 2016
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New formulation of old aspirin for better delivery

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Abstract

For better use of cyclooxygenase dependent anti-inflammatory properties and mitochondrial activities of aspirin, new hydrophobic analogues of aspirin were developed and successfully encapsulated in polymeric nanoparticles (NPs). In vivo anti-inflammatory effects of these NPs using a mouse model demonstrated unique properties of an optimized aspirin analogue to inhibit production of pro-inflammatory and enrichment of anti-inflammatory cytokines.

Graphical abstract: New formulation of old aspirin for better delivery

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Article information


Submitted
31 Aug 2015
Accepted
16 Oct 2015
First published
16 Oct 2015

Chem. Commun., 2016,52, 140-143
Article type
Communication

New formulation of old aspirin for better delivery

A. A. Kalathil, A. Kumar, B. Banik, T. A. Ruiter, R. K. Pathak and S. Dhar, Chem. Commun., 2016, 52, 140
DOI: 10.1039/C5CC07316B

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