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Issue 1, 2016
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New formulation of old aspirin for better delivery

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Abstract

For better use of cyclooxygenase dependent anti-inflammatory properties and mitochondrial activities of aspirin, new hydrophobic analogues of aspirin were developed and successfully encapsulated in polymeric nanoparticles (NPs). In vivo anti-inflammatory effects of these NPs using a mouse model demonstrated unique properties of an optimized aspirin analogue to inhibit production of pro-inflammatory and enrichment of anti-inflammatory cytokines.

Graphical abstract: New formulation of old aspirin for better delivery

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Publication details

The article was received on 31 Aug 2015, accepted on 16 Oct 2015 and first published on 16 Oct 2015


Article type: Communication
DOI: 10.1039/C5CC07316B
Citation: Chem. Commun., 2016,52, 140-143

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    New formulation of old aspirin for better delivery

    A. A. Kalathil, A. Kumar, B. Banik, T. A. Ruiter, R. K. Pathak and S. Dhar, Chem. Commun., 2016, 52, 140
    DOI: 10.1039/C5CC07316B

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