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Issue 92, 2015
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Brønsted acid-catalyzed Mannich reaction through dual activation of aldehydes and N-Boc-imines

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Abstract

In the presence of a Brønsted acid catalyst, both aldehydes and N-Boc-aminals were converted to enecarbamates and N-Boc-iminium salts as activated nucleophiles and electrophiles, respectively, giving unprecedented Mannich adducts. The asymmetric variant of the present Mannich reaction has also been demonstrated with a chiral phosphoric acid catalyst.

Graphical abstract: Brønsted acid-catalyzed Mannich reaction through dual activation of aldehydes and N-Boc-imines

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Publication details

The article was received on 31 Aug 2015, accepted on 15 Sep 2015 and first published on 15 Sep 2015


Article type: Communication
DOI: 10.1039/C5CC07290E
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Citation: Chem. Commun., 2015,51, 16472-16474

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    Brønsted acid-catalyzed Mannich reaction through dual activation of aldehydes and N-Boc-imines

    T. Kano, Y. Aota, D. Asakawa and K. Maruoka, Chem. Commun., 2015, 51, 16472
    DOI: 10.1039/C5CC07290E

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