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Replacement of deoxyguanosine (dG) nucleobases within G-tetrads of G-quadruplex folding oligonucleotides with donor (D)/acceptor (A) fluorescent 8aryldG residues provides diagnostic FRET signalling for G-quadruplex detection.

Graphical abstract: Dual fluorescent deoxyguanosine mimics for FRET detection of G-quadruplex folding

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