Issue 86, 2015
From the journal:

Chemical Communications

The insulin degrading enzyme activates ubiquitin and promotes the formation of K48 and K63 diubiquitin†

G. Grasso,a   V. Lanza,b   G. Malgieri,c   R. Fattorusso,c   A. Pietropaolo,d   E. Rizzarelliab  and  D. Milardi*b  

* Corresponding authors

a Dipartimento di Scienze Chimiche, Università degli Studi di Catania, V.le A. Doria 6, 95125 Catania, Italy

b Istituto di Biostrutture e Bioimmagini, Consiglio Nazionale delle Ricerche, Via P. Gaifami 18, 95126 Catania, Italy
E-mail: danilo.milardi@cnr.it

c Dipartimento di Scienze e Tecnologie Ambientali Biologiche e Farmaceutiche, Seconda Università degli Studi di Napoli, Via Vivaldi 43, 81100 Caserta, Italy

d Dipartimento di Scienze della Salute, Università degli Studi Magna Graecia di Catanzaro, Viale Europa, Catanzaro, Italy

Abstract

We report an ATP-dependent ubiquitin conjugation with IDE which, in turn, promotes Ub–Ub linkages in tube tests. We propose a novel function for IDE as a non-canonical ubiquitin activating enzyme.

Graphical abstract: The insulin degrading enzyme activates ubiquitin and promotes the formation of K48 and K63 diubiquitin

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Article information

DOI
https://doi.org/10.1039/C5CC06786C
Article type
Communication
Submitted
12 Aug 2015
Accepted
03 Sep 2015
First published
03 Sep 2015

Chem. Commun., 2015,51, 15724-15727

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The insulin degrading enzyme activates ubiquitin and promotes the formation of K48 and K63 diubiquitin

G. Grasso, V. Lanza, G. Malgieri, R. Fattorusso, A. Pietropaolo, E. Rizzarelli and D. Milardi, Chem. Commun., 2015, 51, 15724 DOI: 10.1039/C5CC06786C

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