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Issue 7, 2016
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Enhanced target recognition of nanoparticles by cocktail PEGylation with chains of varying lengths

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Abstract

Monodispersed gold nanoparticles (AuNPs) were simultaneously decorated with lactosylated and non-modified shorter poly(ethylene glycol)s (PEGs) to enhance their target recognition. The decoration with sufficiently shorter PEGs dramatically enhanced the multivalent binding ability of lactosylated AuNPs to the lectin-fixed surface, possibly due to the enhanced mobility of the ligands via the spacer effect generated by the shorter PEG chains.

Graphical abstract: Enhanced target recognition of nanoparticles by cocktail PEGylation with chains of varying lengths

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Supplementary files

Article information


Submitted
08 Aug 2015
Accepted
24 Nov 2015
First published
25 Nov 2015

Chem. Commun., 2016,52, 1517-1519
Article type
Communication
Author version available

Enhanced target recognition of nanoparticles by cocktail PEGylation with chains of varying lengths

T. Ishii, K. Miyata, Y. Anraku, M. Naito, Y. Yi, T. Jinbo, S. Takae, Y. Fukusato, M. Hori, K. Osada and K. Kataoka, Chem. Commun., 2016, 52, 1517
DOI: 10.1039/C5CC06661A

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