Asymmetric bromine–lithium exchange: on the importance of both the diamine ligand and the organolithium reagent†
Abstract
The asymmetric bromine–lithium exchange on a series of prochiral biphenyls was investigated. As in many asymmetric organolithium reactions, the chiral ligand (here a diamine) was considered to be the enantiocontrolling element. We show here that the organolithium reagent also plays an important role.