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Issue 98, 2015
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Surface engineering of macrophages with nucleic acid aptamers for the capture of circulating tumor cells

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Abstract

In order to enhance the interactions between macrophages and cancer cells, thiol-terminated nucleic acid aptamers were immobilized on methacryloyl-functionalised carbohydrates of macrophages. The adhesion of cancer cells on the surface modified macrophages was significantly accelerated.

Graphical abstract: Surface engineering of macrophages with nucleic acid aptamers for the capture of circulating tumor cells

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Supplementary files

Article information


Submitted
24 Jul 2015
Accepted
05 Oct 2015
First published
07 Oct 2015

Chem. Commun., 2015,51, 17428-17430
Article type
Communication
Author version available

Surface engineering of macrophages with nucleic acid aptamers for the capture of circulating tumor cells

S. Sugimoto, R. Moriyama, T. Mori and Y. Iwasaki, Chem. Commun., 2015, 51, 17428
DOI: 10.1039/C5CC06211J

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