Issue 98, 2015
From the journal:

Chemical Communications

Surface engineering of macrophages with nucleic acid aptamers for the capture of circulating tumor cells†

Shunsuke Sugimoto,a   Rui Moriyama,ab   Takeshi Moric  and  Yasuhiko Iwasaki*a  

* Corresponding authors

a Department of Chemistry and Materials Engineering, Faculty of Chemistry, Materials and Bioengineering, Kansai University, 3-3-35 Yamate-cho, Suita-shi, Osaka 564-8680, Japan
E-mail: yasu.bmt@kansai-u.ac.jp

b Department of Applied Chemistry, Kyushu Institute of Technology, 1-1 Sensui-cho, Tobata-ku, Kitakyushu-shi, Fukuoka 804-0015, Japan

c Department of Applied Chemistry, Faculty of Engineering, Kyushu University, Fukuoka 812-8581, Japan

Abstract

In order to enhance the interactions between macrophages and cancer cells, thiol-terminated nucleic acid aptamers were immobilized on methacryloyl-functionalised carbohydrates of macrophages. The adhesion of cancer cells on the surface modified macrophages was significantly accelerated.

Graphical abstract: Surface engineering of macrophages with nucleic acid aptamers for the capture of circulating tumor cells

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Article information

DOI
https://doi.org/10.1039/C5CC06211J
Article type
Communication
Submitted
24 Jul 2015
Accepted
05 Oct 2015
First published
07 Oct 2015

Chem. Commun., 2015,51, 17428-17430

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Surface engineering of macrophages with nucleic acid aptamers for the capture of circulating tumor cells

S. Sugimoto, R. Moriyama, T. Mori and Y. Iwasaki, Chem. Commun., 2015, 51, 17428 DOI: 10.1039/C5CC06211J

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