3-Aza π-allyl palladium derived from imino migration in palladium-carbene: MCRs toward multiple substituted indole skeleton†
Abstract
Palladium-catalyzed multi-component reactions (MCRs) between 2-iodoaniline, aryl isonitrile, N-tosylhydrazones and solvent were developed. This procedure features the migration of the imino group in palladium-carbene to produce a 3-aza π-allyl palladium species. Then, intramolecular nucleophilic attack of the π-allyl palladium species by the amino group takes place facilely, thus producing a 1,2,3-trisubstitued indole skeleton, which has high diversity and complexity.