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Issue 74, 2015
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Application of Good's buffers to pH imaging using hyperpolarized 13C MRI

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Abstract

N-(2-Acetamido)-2-aminoethanesulfonic acid (ACES), one of Good's buffers, was applied to pH imaging using hyperpolarized 13C magnetic resonance spectroscopy. Rapid NMR- and MRI-based pH measurements were obtained by exploiting the sensitive pH-dependence of its 13C chemical shift within the physiologic range.

Graphical abstract: Application of Good's buffers to pH imaging using hyperpolarized 13C MRI

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Publication details

The article was received on 29 Jun 2015, accepted on 03 Aug 2015 and first published on 03 Aug 2015


Article type: Communication
DOI: 10.1039/C5CC05348J
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Chem. Commun., 2015,51, 14119-14122

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    Application of Good's buffers to pH imaging using hyperpolarized 13C MRI

    R. R. Flavell, C. von Morze, J. E. Blecha, D. E. Korenchan, M. Van Criekinge, R. Sriram, J. W. Gordon, H. Chen, S. Subramaniam, R. A. Bok, Z. J. Wang, D. B. Vigneron, P. E. Larson, J. Kurhanewicz and D. M. Wilson, Chem. Commun., 2015, 51, 14119
    DOI: 10.1039/C5CC05348J

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