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Issue 73, 2015
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Amorphous metal–organic frameworks for drug delivery

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Abstract

We report the encapsulation of the hydrophilic model molecule calcein in the Zr-based MOF UiO-66, followed by amorphization of the framework by ball-milling. We show controlled release of calcein over more than 30 days, compared with the 2 day release period from crystalline UiO-66.

Graphical abstract: Amorphous metal–organic frameworks for drug delivery

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Article information


Submitted
25 Jun 2015
Accepted
21 Jul 2015
First published
21 Jul 2015

Chem. Commun., 2015,51, 13878-13881
Article type
Communication
Author version available

Amorphous metal–organic frameworks for drug delivery

C. Orellana-Tavra, E. F. Baxter, T. Tian, T. D. Bennett, N. K. H. Slater, A. K. Cheetham and D. Fairen-Jimenez, Chem. Commun., 2015, 51, 13878
DOI: 10.1039/C5CC05237H

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