Issue 77, 2015
From the journal:

Chemical Communications

A peptide-based pH-sensitive drug delivery system for targeted ablation of cancer cells†

Yulong Jin,a   Yanyan Huang,*a   Hua Yang,b   Guoquan Liua  and  Rui Zhao*a  

* Corresponding authors

a Beijing National Laboratory for Molecular Sciences, CAS Key Laboratories of Analytical Chemistry for Living Biosystems, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China
E-mail: yyhuang@iccas.ac.cn, zhaorui@iccas.ac.cn

b Department of Cell Biology, School of Basic Medical Sciences, Peking University, Beijing, China

Abstract

A peptide-guided prodrug incorporating a tumor-specific peptide, doxorubicin, and a pH-sensitive hydrazone bridge was developed for targeted ablation of cancer cells with minimal side cytotoxicity.

Graphical abstract: A peptide-based pH-sensitive drug delivery system for targeted ablation of cancer cells

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Article information

DOI
https://doi.org/10.1039/C5CC05184C
Article type
Communication
Submitted
24 Jun 2015
Accepted
05 Aug 2015
First published
05 Aug 2015

Chem. Commun., 2015,51, 14454-14457

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A peptide-based pH-sensitive drug delivery system for targeted ablation of cancer cells

Y. Jin, Y. Huang, H. Yang, G. Liu and R. Zhao, Chem. Commun., 2015, 51, 14454 DOI: 10.1039/C5CC05184C

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